• Corpus ID: 82316237

Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Gamma (RORγ)

@inproceedings{Kumar2013IdentificationOA,
  title={Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Gamma (ROR$\gamma$)},
  author={Naresh Kumar and Philippe Nuhant and Laura A. Solt and Juliana Johnson Conkright and Yongjun Wang and Monica Adina Istrate and Scott A. Busby and D. Garcia-Ordonez Ruben and Thomas P. Burris and Michael D. Cameron and Becky A. Mercer and Peter S. Hodder and William R. Roush and Hugh Rosen and Patrick R. Griffin},
  year={2013}
}
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Circadian factors BMAL1 and RORα control HIF-1α transcriptional activity in nucleus pulposus cells: implications in maintenance of intervertebral disc health

Results indicate that BMAL1 and RORα form a regulatory loop in the NP and control HIF-1 activity without direct interaction, and activities of these circadian rhythm molecules may play a role in the adaptation of NP cells to their unique niche.

ROR: Nuclear Receptor for Melatonin or Not?

The latest evidence and views on direct binding as well as indirect regulation of ROR by melatonin are provided, dissecting both viewpoints in-depth to provide a more comprehensive perspective on this issue.