Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript

  title={Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript},
  author={Zsofia Kote-Jarai and Ali Amin Al Olama and Daniel A. Leongamornlert and Malgorzata Tymrakiewicz and Edward J. Saunders and Michelle Guy and Graham G. Giles and Gianluca Severi and M C Southey and J. L. Hopper and Kei Chun Sit and Jonathan M. Harris and Jyotsna Batra and Amanda B Spurdle and Judith Ann Clements and Freddie C. Hamdy and David Neal and Jenny L Donovan and Kenneth Ross Muir and Paul D P Pharoah and Stephen J. Chanock and Nathan Brown and Sara Benlloch and Elena Castro and Niaz Uddin Mahmud and Lorraine O’Brien and Allan Hall and Elinor Sawyer and Rosalie Wilkinson and Douglas F. Easton and Rosalind A. Eeles},
  booktitle={Human Genetics},
Genome-wide association studies (GWAS) have identified more than 30 prostate cancer (PrCa) susceptibility loci. One of these (rs2735839) is located close to a plausible candidate susceptibility gene, KLK3, which encodes prostate-specific antigen (PSA). PSA is widely used as a biomarker for PrCa detection and disease monitoring. To refine the association between PrCa and variants in this region, we used genotyping data from a two-stage GWAS using samples from the UK and Australia, and the Cancer… CONTINUE READING


Publications referenced by this paper.

cancer risk - associated variants on clinicopath - ologic variables in 5 , 895 prostate cancer patients

  • MG Lawrence, J Lai, JA Clements
  • 2010
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