Identification of a novel prophage-like gene cluster actively expressed in both virulent and avirulent strains of Leptospira interrogans serovar Lai.

@article{Qin2008IdentificationOA,
  title={Identification of a novel prophage-like gene cluster actively expressed in both virulent and avirulent strains of Leptospira interrogans serovar Lai.},
  author={Jin-Hong Qin and Qing Zhang and Zhi-ming Zhang and Yi Zhong and Yang Yang and Bao-yu Hu and Guo-Ping Zhao and Xiaokui Guo},
  journal={Infection and immunity},
  year={2008},
  volume={76 6},
  pages={2411-9}
}
DNA microarray analysis was used to compare the differential gene expression profiles between Leptospira interrogans serovar Lai type strain 56601 and its corresponding attenuated strain IPAV. A 22-kb genomic island covering a cluster of 34 genes (i.e., genes LA0186 to LA0219) was actively expressed in both strains but concomitantly upregulated in strain 56601 in contrast to that of IPAV. Reverse transcription-PCR assays proved that the gene cluster comprised five transcripts. Gene annotation… CONTINUE READING
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