Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.

@article{Lee2012IdentificationOA,
  title={Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.},
  author={Kyung Ho Lee and Yoshikazu Johmura and L Yu and Jung-Eun Park and Yuan Gao and Jeong Kyu Bang and Ming Zhou and Timothy D. Veenstra and Bo Yeon Kim and Kyung S Lee},
  journal={The EMBO journal},
  year={2012},
  volume={31 14},
  pages={3104-17}
}
Non-motile primary cilium is an antenna-like structure whose defect is associated with a wide range of pathologies, including developmental disorders and cancer. Although mechanisms regulating cilia assembly have been extensively studied, how cilia disassembly is regulated remains poorly understood. Here, we report unexpected roles of Dishevelled 2 (Dvl2) and interphase polo-like kinase 1 (Plk1) in primary cilia disassembly. We demonstrated that Dvl2 is phosphorylated at S143 and T224 in a… CONTINUE READING
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