Identification of a novel partner of RNA polymerase II subunit 11, Che‐1, which interacts with and affects the growth suppression function of Rb

  title={Identification of a novel partner of RNA polymerase II subunit 11, Che‐1, which interacts with and affects the growth suppression function of Rb},
  author={Maurizio Fanciulli and Tiziana Bruno and Monica Di Padova and Roberta De Angelis and Simona Iezzi and Carla Iacobini and Aristide Floridi and Claudio Passananti},
  journal={The FASEB Journal},
  pages={904 - 912}
hRPB11 is a core subunit of RNA polymerase II (pol II) specifically down‐regulated on doxorubicin (dox) treatment. Levels of this protein profoundly affect cell differentiation, cell proliferation, and tumorigenicity in vivo. Here we describe Che‐1, a novel human protein that interacts with hRPB11. Che‐1 possesses a domain of high homol‐ogy with Escherichia coli RNA polymerase σ‐factor 70 and SV40 large T antigen. In addition, we report that Che‐1 interacts with the retinoblastoma… 

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