Identification of a novel nuclear domain

  title={Identification of a novel nuclear domain},
  author={Carl A. Ascoli and G. Maul},
  journal={The Journal of Cell Biology},
  pages={785 - 795}
For most known nuclear domains (ND), specific functions have been identified. In this report we used murine mAbs and human autoantibodies to investigate precisely circumscribed structures 0.2-0.3 micron in diameter which appear as "nuclear dots" distributed throughout the nucleoplasm. Nuclear dots are metabolically stable and resistant to nuclease digestion and salt extraction. The localization of nuclear dots is separate from kinetochores, centromeres, sites of mRNA processing and tRNA… CONTINUE READING
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