Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans.

Abstract

The metabolism of phenanthrene by the fungus Cunninghamella elegans was investigated. Kinetic experiments using [9-14C]phenanthrene showed that after 72 h, 53% of the total radioactivity was associated with a glucoside conjugate of 1-hydroxyphenanthrene (phenanthrene 1-O-beta-glucose). This metabolite was isolated by reversed-phase high-performance liquid chromatography and characterized by the application of UV absorption, 1H nuclear magnetic resonance, and mass spectral techniques. The results show that aromatic ring oxidation followed by glucosylation is a predominant pathway in the metabolism of the polycyclic aromatic hydrocarbon phenanthrene by C. elegans.

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@article{Cerniglia1989IdentificationOA, title={Identification of a novel metabolite in phenanthrene metabolism by the fungus Cunninghamella elegans.}, author={Carl Cerniglia and Warren L. Campbell and James P. Freeman and Frederick E. Evans}, journal={Applied and environmental microbiology}, year={1989}, volume={55 9}, pages={2275-9} }