Identification of a novel member of the T1R family of putative taste receptors

  title={Identification of a novel member of the T1R family of putative taste receptors},
  author={Eduardo Sainz and Julius N. Korley and James F. Battey and Susan L. Sullivan},
  journal={Journal of Neurochemistry},
In the gustatory system, the recognition of sugars, amino acids and bitter‐tasting compounds is the function of specialized G protein‐coupled receptors. Recently, two members of novel subfamily of G protein‐coupled receptors were proposed to function as taste receptors based on their specific expression in taste receptor cells. Here, we report the identification of a third member, T1R3, of this family of receptors. T1R3 maps near the telomere of mouse chromosome 4 rendering it a candidate for… 
Identification and characterization of human taste receptor genes belonging to the TAS2R family
Phylogenetic analyses suggest a classification of the TAS2R genes in five groups that may reflect a specialization in the detection of specific types of bitter chemicals.
Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose
It is demonstrated for the first time that the candidate sweet taste receptor T1R3 is essential for the recognition and response to the disaccharide trehalose.
Mammalian Sweet Taste Receptors
Three sweet receptor genes are clustered in human Chromosome 1
All three hT1Rs genes are expressed selectively in human taste receptor cells in the fungiform papillae, consistent with their role in taste perception.
Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3
It is shown that mice lacking T1r3 showed no preference for artificial sweeteners and had diminished but not abolished behavioral and nerve responses to sugars and umami compounds, indicating that T1 r3-independent sweet- andUmami-responsive receptors and/or pathways exist in taste cells.
T1R receptors mediate mammalian sweet and umami taste.
  • Xiaodong Li
  • Biology
    The American journal of clinical nutrition
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A cooperative ligand binding model that involved the Venus flytrap domain of T1R1 in which l-glutamate binds close to the hinge region and 5' ribonucleotides bind to an adjacent site close toThe opening of the flytrap to further stabilize the closed conformation is proposed.
Taste receptor genes.
Progress with understanding how T1R and T2R receptors interact with taste stimuli and with identifying their patterns of expression in taste cells sheds light on coding of taste information by the nervous system.
New insights into the characteristics of sweet and bitter taste receptors.
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  • Biology
    International review of cell and molecular biology
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A family of candidate taste receptors in human and mouse
The identification of a family of candidate taste receptors (the TRBs) that are members of the G-protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells are reported.
A metabotropic glutamate receptor variant functions as a taste receptor
A GPCR cloned from rat taste buds and functionally expressed in CHO cells is described, which shows an unusual concentration–response relationship and the similarity of its properties to MSG taste suggests that this receptor is a taste receptor for glutamate.
T2Rs Function as Bitter Taste Receptors
Putative pheromone receptors related to the Ca2+-sensing receptor in Fugu.
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  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1998
A large family of genes related to the Ca2+-sensing receptor from the genome of Fugu rubripes are isolated by a combination of PCR with degenerate primers and low stringency probing, appearing to be the homologues of the vomeronasal pheromone receptors recently described in rodents.
The G protein-coupling profile of metabotropic glutamate receptors, as determined with exogenous G proteins, is independent of their ligand recognition domain.
It is shown that the extracellular domain determines the agonist pharmacological profile and that this domain does not modify the G protein-coupling profile determined by the seven-transmembrane-domain region of mGlu receptors.
Mechanisms of taste transduction