Identification of a novel lncRNA in gluteal adipose tissue and evidence for its positive effect on preadipocyte differentiation

  title={Identification of a novel lncRNA in gluteal adipose tissue and evidence for its positive effect on preadipocyte differentiation},
  author={Adeline Divoux and Kalypso Karastergiou and Hui Xie and Guo Weimin and Ranjan J. Perera and Susan K. Fried and Steven R. Smith},
OBJECTIVE Peripheral lower body fat is associated with lower cardiometabolic risk. Physiological differences in gluteal compared with abdominal subcutaneous (sc) adipocyte functions are known but the molecular basis for depot differences in adipocyte function is poorly understood. Our goal is to identify novel gene regulatory pathways that underlie the heterogeneity of human fat distribution. METHODS Abdominal and gluteal adipose tissue aspirates obtained from 35 subjects (age = 30 ± 1.6… CONTINUE READING
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Long noncoding RNAs regulate adipogenesis.

Proceedings of the National Academy of Sciences of the United States of America • 2013
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