Identification of a novel linear B-cell epitope using a monoclonal antibody against the carboxy terminus of the canine distemper virus nucleoprotein and sequence analysis of the identified epitope in different CDV isolates

Abstract

The Nucleoprotein (NP) is the most abundant and highly immunogenic protein in canine distemper virus (CDV), playing an important role in CDV viral replication and assembly. In this study, a specific monoclonal antibody, named C8, was produced against the NP protein C terminal (amino acids 401–523). A linear N protein epitope was identified by subjecting a… (More)
DOI: 10.1186/s12985-017-0858-6

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@inproceedings{Yi2017IdentificationOA, title={Identification of a novel linear B-cell epitope using a monoclonal antibody against the carboxy terminus of the canine distemper virus nucleoprotein and sequence analysis of the identified epitope in different CDV isolates}, author={Li Yi and Zhigang Cao and Mingwei Tong and Yuening Cheng and Yong Yang and Shuang Li and Jianke Wang and Peng Lin and Yaru Sun and Miao Zhang and Shipeng Cheng}, booktitle={Virology Journal}, year={2017} }