Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes

@inproceedings{Choi2000IdentificationOA,
  title={Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes},
  author={Young Hun Choi and Dag Ekholm and Judith Krall and Faiyaz Ahmad and Eva Degerman and Vincent C. Manganiello and Matthew A. Movsesian},
  year={2000}
}
  • Young Hun Choi, Dag Ekholm, +4 authors Matthew A. Movsesian
  • Published 2000
  • Biology
  • We have identified a new cyclic-nucleotide phosphodiesterase isoform, PDE3A, and cloned its cDNA from cultured aortic myocytes. The nucleotide sequence of its coding region is similar to that of the previously cloned myocardial isoform except for the absence of the initial 300-400 nt that are present in the latter, as confirmed by reverse-transcriptase-mediated PCR, 5' rapid amplification of cDNA ends and a ribonuclease protection assay. Expression in Spodoptera frugiperda (Sf9) cells yields a… CONTINUE READING

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