Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor.

@article{Yang1999IdentificationOA,
  title={Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor.},
  author={Junhao Yang and Masatsugu Hori and Takaomi Sanda and Takashi Okamoto},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 22},
  pages={15662-70}
}
Here we report the identification and characterization of a novel protein, RelA-associated inhibitor (RAI), that binds to the NF-kappaB subunit p65 (RelA) and inhibits its transcriptional activity. RAI gene was isolated in a yeast two-hybrid screen using the central region of p65 as bait. We confirmed the physical interaction in vitro using recombinant proteins as well as in vivo by immunoprecipitation/Western blot assay. RAI gene encodes a protein with homology to the C-terminal region of… CONTINUE READING

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