Identification of a novel inflammatory stimulant of chondrocytes. Early events in cell activation by bradykinin receptors on pig articular chondrocytes.

@article{Benton1989IdentificationOA,
  title={Identification of a novel inflammatory stimulant of chondrocytes. Early events in cell activation by bradykinin receptors on pig articular chondrocytes.},
  author={H. Paul Benton and Trevor R. Jackson and Michael R. Hanley},
  journal={The Biochemical journal},
  year={1989},
  volume={258 3},
  pages={861-7}
}
The inflammatory peptide bradykinin stimulated a rapid and transient increase in cytoplasmic [Ca2+] in primary pig chondrocytes, as measured by the fluorescent indicator dye Fura-2. This increase occurred in the absence of extracellular Ca2+, indicating a mobilization from intracellular stores. The elevation in intracellular [Ca2+] was mediated by authentic… CONTINUE READING