Identification of a novel immunodominant antigen Rv2645 from RD13 with potential as a cell-mediated immunity-based TB diagnostic agent.

@article{Luo2015IdentificationOA,
  title={Identification of a novel immunodominant antigen Rv2645 from RD13 with potential as a cell-mediated immunity-based TB diagnostic agent.},
  author={Wei Luo and Zi-Lu Qu and Yan Qing Xie and Jie Xiang and Xiao-Lian Zhang},
  journal={The Journal of infection},
  year={2015},
  volume={71 5},
  pages={534-43}
}
Search for novel specific antigens are urgently needed for the detection of tuberculosis (TB). In this study, we evaluated the diagnostic potential of a novel Mycobacterium tuberculosis (M.tb)-specific candidate antigen (Rv2645) from DNA segment region of differentiation (RD) 13 of M.tb and investigated T-cell recognition during natural infection in humans and experimental mice. Rv2645-specific IFN-γ levels were much higher in the peripheral blood mononuclear cells (PBMCs) of TB patients than… CONTINUE READING

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