Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood.

@article{Ingram2004IdentificationOA,
  title={Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood.},
  author={D. Ingram and L. Mead and Hiromi Tanaka and V. Meade and Amy Fenoglio and K. Mortell and K. Pollok and M. Ferkowicz and D. Gilley and M. Yoder},
  journal={Blood},
  year={2004},
  volume={104 9},
  pages={
          2752-60
        }
}
Emerging evidence to support the use of endothelial progenitor cells (EPCs) for angiogenic therapies or as biomarkers to assess cardiovascular disease risk and progression is compelling. However, there is no uniform definition of an EPC, which makes interpretation of these studies difficult. Although hallmarks of stem and progenitor cells are their ability to proliferate and to give rise to functional progeny, EPCs are primarily defined by the expression of cell-surface antigens. Here, using… Expand
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A great deal of attention has been recently focused on understanding the role that bone marrow‐derived putative endothelial progenitor cells (EPC) may play in the process of neoangiogenesis. However,Expand
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Although these two EPCs expressed different phenotypes, including growth factor receptors, and had different proliferative ability, they both eventually differentiated into mature ECs after more than 3 weeks of culture. Expand
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Analysis of the lineage relationship between, and angiogenic function of, early endothelial progenitor cells (EPCs) and late outgrowth endothelial cells (OECs) in culture indicates lineage and functional heterogeneity in the population of circulating cells capable of assuming an endothelial phenotype. Expand
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TLDR
Two types of EPC are found from a source of adult peripheral blood that might have different roles in neovasculogenesis based on the identified differences, suggesting that EPC is not a single type of cell population. Expand
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