Identification of a novel growth factor-responsive gene in vascular smooth muscle cells.

  title={Identification of a novel growth factor-responsive gene in vascular smooth muscle cells.},
  author={Stephen D Wax and C L Rosenfield and Mark B. Taubman},
  journal={The Journal of biological chemistry},
  volume={269 17},
We have employed differential screening of a rat aortic smooth muscle cell cDNA library to isolate a cDNA clone, SM-20, whose nucleotide and deduced amino acid sequences are distinct from those reported previously. SM-20 encodes an mRNA of approximately 2.5-3.0 kilobase pairs which is present at low levels in quiescent vascular smooth muscle cells. SM-20 levels increase within 1 h of treatment with growth agonists (serum, platelet-derived growth factor, angiotensin II), isoproterenol, and… CONTINUE READING


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