Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family.

@article{Zebhauser2005IdentificationOA,
  title={Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family.},
  author={Roland Zebhauser and Robert Kammerer and Andreas Eisenried and Andrew McLellan and Tom Moore and Wolfgang Zimmermann},
  journal={Genomics},
  year={2005},
  volume={86 5},
  pages={566-80}
}
The carcinoembryonic antigen (CEA) family comprises a still actively evolving populous group of proteins that are involved in controlling tissue homeostasis, immune responses, and host/pathogen interactions. The genes identified to date in rodents and primates exhibit low sequence similarity and an extremely variable domain composition. Among the 22 murine Cea-related genes, only for Ceacam1 has an ortholog been assigned. To identify all CEA-related genes in mouse, rat, and human we undertook… CONTINUE READING

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