Identification of a novel gene family involved in osmotic stress response in Caenorhabditis elegans.

@article{Wheeler2006IdentificationOA,
  title={Identification of a novel gene family involved in osmotic stress response in Caenorhabditis elegans.},
  author={Jeanna M. Wheeler and James Harold Thomas},
  journal={Genetics},
  year={2006},
  volume={174 3},
  pages={1327-36}
}
Organisms exposed to the damaging effects of high osmolarity accumulate solutes to increase cytoplasmic osmolarity. Yeast accumulates glycerol in response to osmotic stress, activated primarily by MAP kinase Hog1 signaling. A pathway regulated by protein kinase C (PKC1) also responds to changes in osmolarity and cell wall integrity. C. elegans accumulates glycerol when exposed to high osmolarity, but the molecular pathways responsible for this are not well understood. We report the… CONTINUE READING

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