Identification of a novel gene expressed in activated natural killer cells and T cells.

@article{Dahl1992IdentificationOA,
  title={Identification of a novel gene expressed in activated natural killer cells and T cells.},
  author={Carol A. Dahl and Rebecca P. Schall and Haiqi He and J. Scott Cairns},
  journal={Journal of immunology},
  year={1992},
  volume={148 2},
  pages={597-603}
}
We have isolated a cDNA clone from a human activated NK cell-derived cDNA library that identifies a transcript (NK4) that is selectively expressed in lymphocytes. The expression of this transcript is increased after activation of T cells by mitogens or activation of NK cells by IL-2 (lymphokine-activated killer cells). The transcript levels demonstrated by Northern blot analysis increase by 12 h after activation, remain high for at least 48 h, and require protein synthesis for expression… CONTINUE READING

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