Identification of a novel gene HEPT3 that is overexpressed in human hepatocellular carcinoma and may function through its noncoding RNA.

@article{Moh2007IdentificationOA,
  title={Identification of a novel gene HEPT3 that is overexpressed in human hepatocellular carcinoma and may function through its noncoding RNA.},
  author={Mei Chung Moh and Lay Hoon Lee and Xiaodong Yang and Shali Shen},
  journal={International journal of oncology},
  year={2007},
  volume={31 2},
  pages={
          293-301
        }
}
Genetic alterations have been defined as the hallmark of cancers as they are responsible for the differences between normal and malignant phenotypes. A widely accepted approach to study genetic instability is to identify cancer-related genes, in particular, the two major groups of growth regulatory genes - oncogenes and tumour suppressor genes. Using the technique of suppression subtractive hybridisation, we identified a novel gene transcript, designated as HEPT3. RT-PCR demonstrated that HEPT3… CONTINUE READING

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