Identification of a novel function of the alphavirus capping apparatus. RNA 5'-triphosphatase activity of Nsp2.

@article{Vasiljeva2000IdentificationOA,
  title={Identification of a novel function of the alphavirus capping apparatus. RNA 5'-triphosphatase activity of Nsp2.},
  author={Lidia Vasiljeva and Andres Merits and Petri Auvinen and Leevi K{\"a}{\"a}ri{\"a}inen},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 23},
  pages={17281-7}
}
Both genomic and subgenomic RNAs of the Alphavirus have m(7)G(5')ppp(5')N (cap0 structure) at their 5' end. Previously it has been shown that Alphavirus-specific nonstructural protein Nsp1 has guanine-7N-methyltransferase and guanylyltransferase activities needed in the synthesis of the cap structure. During normal cap synthesis the 5' gamma-phosphate of the nascent viral RNA chain is removed by a specific RNA 5'-triphosphatase before condensation with GMP, delivered by the guanylyltransferase… CONTINUE READING

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