Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility.

@article{Vale1985IdentificationOA,
  title={Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility.},
  author={Ronald D. Vale and Thomas S. Reese and Michael P Sheetz},
  journal={Cell},
  year={1985},
  volume={42 1},
  pages={39-50}
}
Axoplasm from the squid giant axon contains a soluble protein translocator that induces movement of microtubules on glass, latex beads on microtubules, and axoplasmic organelles on microtubules. We now report the partial purification of a protein from squid giant axons and optic lobes that induces these microtubule-based movements and show that there is a homologous protein in bovine brain. The purification of the translocator protein depended primarily on its unusual property of forming a high… CONTINUE READING
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