Identification of a novel family of presenilin homologues.

  title={Identification of a novel family of presenilin homologues.},
  author={Chris Paul Ponting and Michael L. Hutton and Andrew C. Nyborg and Matthew Baker and Karen R. Jansen and Todd E. Golde},
  journal={Human molecular genetics},
  volume={11 9},
Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Presenilins have been shown to influence limited proteolysis of amyloid beta protein precursor (APP), Notch and ErbB4, and have been proposed to be gamma-secretases that perform the terminal cleavage of APP. In this model, two conserved and apparently intramembranous aspartic acids participate in catalysis. Highly sequence-similar presenilin homologues are known… 

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