Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells.

@article{Muccioli2007IdentificationOA,
  title={Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells.},
  author={Giulio G Muccioli and Cong Xu and Emma Odah and Eiron Cudaback and Jos{\'e} Antonio Cisneros and Didier Lambert and Mar{\'i}a Luz L{\'o}pez Rodr{\'i}guez and Sandra M. Bajjalieh and Nephi Stella},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 11},
  pages={2883-9}
}
The endocannabinoids (eCBs) anandamide and 2-arachidonoyl glycerol (2-AG) are inactivated by a two-step mechanism. First, they are carried into cells, and then anandamide is hydrolyzed by fatty acid amide hydrolase (FAAH) and 2-AG by monoacylglycerol lipase (MGL). Here we provide evidence for a previously undescribed MGL activity expressed by microglial cells. We found that the mouse microglial cell line BV-2 does not express MGL mRNA and yet efficiently hydrolyzes 2-AG. URB597 (3'-carbamoyl… CONTINUE READING