Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval.

Abstract

The cation-independent mannose 6-phosphate receptor (CIMPR) cycles between the trans-Golgi network (TGN) and endosomes to mediate sorting of lysosomal hydrolases. The endosome-to-TGN retrieval of the CIMPR requires the retromer complex. Genetic, biochemical and structural data support the hypothesis that the retromer can directly bind to the tail of the… (More)

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@article{Seaman2007IdentificationOA, title={Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval.}, author={Matthew N.J. Seaman}, journal={Journal of cell science}, year={2007}, volume={120 Pt 14}, pages={2378-89} }