Identification of a novel antigen of pathogenic Leptospira spp. that reacted with convalescent mice sera.

@article{Koizumi2003IdentificationOA,
  title={Identification of a novel antigen of pathogenic Leptospira spp. that reacted with convalescent mice sera.},
  author={Nobuo Koizumi and Haruo Watanabe},
  journal={Journal of medical microbiology},
  year={2003},
  volume={52 Pt 7},
  pages={585-9}
}
The virulence of leptospires isolated from human patients against C3H/HeJ mice was investigated. Infection with clinical isolates from patients with severe leptospirosis was lethal to C3H/HeJ mice, suggesting that C3H/HeJ mice are suitable as an acute lethal model of severe leptospirosis. Using this model, a novel antigen of pathogenic Leptospira spp. (named LAg42), which reacted with convalescent mice sera, was identified. LAg42 is a 42 kDa inner-membrane protein and its immunogenic region is… CONTINUE READING

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