Identification of a novel acidic mammalian chitinase distinct from chitotriosidase.

  title={Identification of a novel acidic mammalian chitinase distinct from chitotriosidase.},
  author={Rolf G. Boot and Edward F C Blommaart and Eric P Swart and Karen Ghauharali-van der Vlugt and Nora Bijl and Christine Moe and Allen Place and Johannes Maria Aerts},
  journal={The Journal of biological chemistry},
  volume={276 9},
Chitinases are ubiquitous chitin-fragmenting hydrolases. Recently we discovered the first human chitinase, named chitotriosidase, that is specifically expressed by phagocytes. We here report the identification, purification, and subsequent cloning of a second mammalian chitinase. This enzyme is characterized by an acidic isoelectric point and therefore named acidic mammalian chitinase (AMCase). In rodents and man the enzyme is relatively abundant in the gastrointestinal tract and is found to a… CONTINUE READING
Highly Influential
This paper has highly influenced 22 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS