Identification of a novel TATA element-binding protein binding region at the N terminus of the Saccharomyces cerevisiae TAF1 protein.

@article{Takahata2003IdentificationOA,
  title={Identification of a novel TATA element-binding protein binding region at the N terminus of the Saccharomyces cerevisiae TAF1 protein.},
  author={Shinya Takahata and Hidei Ryu and Kazushige Ohtsuki and Koji Kasahara and Masashi Kawaichi and Tetsuro Kokubo},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 46},
  pages={
          45888-902
        }
}
TFIID, a multiprotein complex composed of TATA element-binding protein (TBP) and 14 TBP-associated factors (TAFs), can directly recognize core promoter elements and mediate transcriptional activation. The TAF N-terminal domain (TAND) of TAF1 may play a significant role in these two principal TFIID functions by regulating the access of TBP to the TATA element. In yeast, TAND consists of two subdomains, TAND1 (10-37 amino acids (aa)) and TAND2 (46-71 aa), which interact with the concave and… CONTINUE READING
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