Identification of a novel Na+/myo-inositol cotransporter.

@article{Coady2002IdentificationOA,
  title={Identification of a novel Na+/myo-inositol cotransporter.},
  author={Michael J. Coady and Bernadette Wallendorff and Dominique G. Gagnon and J. -Y. Lapointe},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 38},
  pages={
          35219-24
        }
}
rkST1, an orphan cDNA of the SLC5 family (43% identical in sequence to the sodium myo-inositol cotransporter SMIT), was expressed in Xenopus laevis oocytes that were subsequently voltage-clamped and exposed to likely substrates. Whereas superfusion with glucose and other sugars produced a small inward current, the largest current was observed with myo-inositol. The expressed protein, which we have named SMIT2, cotransports myo-inositol with a K(m) of 120 microm and displays a current-voltage… CONTINUE READING
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