Identification of a novel NDM variant, NDM-13, from a multidrug-resistant Escherichia coli clinical isolate in Nepal.

Abstract

A novel New Delhi metallo-β-lactamase, NDM-13, was identified in a carbapenem-resistant Escherichia coli clinical isolate obtained from the urine of a patient in Nepal. The enzymatic activity of NDM-13 against β-lactams was similar to that of NDM-1. However, NDM-13 displayed significantly higher k cat/Km ratios for cefotaxime. The genetic environment of bla NDM-13 was determined to be tnpA-IS30-bla NDM-13-ble MBL-trpF-dsbC-cutA-groES-groL, with bla NDM-13 located within the chromosome.

DOI: 10.1128/AAC.00332-15

2 Figures and Tables

Cite this paper

@article{Shrestha2015IdentificationOA, title={Identification of a novel NDM variant, NDM-13, from a multidrug-resistant Escherichia coli clinical isolate in Nepal.}, author={Basudha Shrestha and Tatsuya Tada and Tohru Miyoshi-Akiyama and Kayo Shimada and Hiroshi Ohara and Teruo Kirikae and Bharat Mani Pokhrel}, journal={Antimicrobial agents and chemotherapy}, year={2015}, volume={59 9}, pages={5847-50} }