Identification of a novel N-cadherin antagonist.

  title={Identification of a novel N-cadherin antagonist.},
  author={Emmanuelle Devemy and Orest William Blaschuk},
  volume={29 11},
The cell adhesion molecule, N-cadherin plays a pivotal role in many biological and disease processes. Drugs that modulate N-cadherin function should therefore be useful therapeutic agents. We have used phage display technology to identify amino acid sequences capable of binding to N-cadherin. All of these sequences harbor a Trp residue in the second position from the N-terminus. A synthetic linear peptide containing one of these sequences, H-SWTLYTPSGQSK-NH(2) was found to bind a chimeric… CONTINUE READING