Identification of a novel HA conformational change inhibitor of human influenza virus

  title={Identification of a novel HA conformational change inhibitor of human influenza virus},
  author={J. N. Yoshimoto and M. Kakui and Hiroshi Iwasaki and Tamaki Fujiwara and Hirohiko Sugimoto and Nachiko Hattori},
  journal={Archives of Virology},
Stachyflin is a novel compound having H1 and H2 subtype-specific anti-influenza A virus activity. Stachyflin has no inhibition on H3 subtype influenza A or influenza B viruses. The susceptibility of the reassortant viruses between H1 and H3 subtype influenza A viruses to Stachyflin indicated that its target was virus-encoded hemagglutinin (HA). The results of the timing of Stachyflin addition against in vitro virus infection and virus-mediated hemolysis assay suggested that the drug inhibited… CONTINUE READING


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