Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions.

@article{Marshall2003IdentificationOA,
  title={Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions.},
  author={Jason D Marshall and Karen L. Fearon and Christi Abbate and Sandhya Subramanian and Priscilla Yee and Josh G Gregorio and Robert Lee Coffman and Gary A. Van Nest},
  journal={Journal of leukocyte biology},
  year={2003},
  volume={73 6},
  pages={781-92}
}
Recent reports have identified two major classes of CpG motif-containing oligodeoxynucleotide immunostimulatory sequences (ISS): uniformly modified phosphorothioate (PS) oligodeoxyribonucleotides (ODNs), which initiate B cell functions but poorly activate dendritic cells (DCs) to make interferon (IFN)-alpha, and chimeric PS/phosphodiester (PO) ODNs containing runs of six contiguous guanosines, which induce very high levels of plasmacytoid DC (PDC)-derived IFN-alpha but poorly stimulate B cells… CONTINUE READING
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A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co - administered with an immunostimmulatory phosphorothioate oligonucleotide adjuvant

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A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimmulatory phosphorothioate oligonucleotide adjuvant. Vaccine, in press

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