Identification of a novel 33-kDa C1q-binding site on human blood platelets.

  title={Identification of a novel 33-kDa C1q-binding site on human blood platelets.},
  author={Ellinor I. B. Peerschke and Ken B. M. Reid and Berhane Ghebrehiwet},
  journal={Journal of immunology},
  volume={152 12},
The constitutive expression of a 60-kDa platelet membrane protein (cC1qR) recognizing the collagen-like amino terminal of C1q was previously described. Recently, a novel 33-kDa C1q receptor (gC1qR) that interacts with the globular head region of C1q was identified on Raji cells, as well as PBLs, neutrophils, and eosinophils. The present study demonstrates that polyclonal Abs directed against this novel C1q-binding protein also recognize a 33-kDa platelet membrane constituent on Western blots… CONTINUE READING

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