Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.

@article{Burtis1987IdentificationOA,
  title={Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.},
  author={William J. Burtis and Tianyun Wu and Christopher Bunch and John J. Wysolmerski and Karl L. Insogna and Eleanor C. Weir and Arthur E. Broadus and Andrew Francis Stewart},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 15},
  pages={7151-6}
}
Humoral hypercalcemia of malignancy is a common paraneoplastic syndrome which is characterized by hypercalcemia resulting from secretion by tumors of a circulating bone-resorbing factor. Evidence suggests that in many instances this factor is an adenylate cyclase-stimulating protein which shares features with, but is distinct from, parathyroid hormone (PTH). The current report describes the purification to homogeneity from a humoral hypercalcemia of malignancy-associated tumor of a novel, basic… CONTINUE READING
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