Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data.

@article{Wang2012IdentificationOA,
  title={Identification of a novel, recurrent HEY1-NCOA2 fusion in mesenchymal chondrosarcoma based on a genome-wide screen of exon-level expression data.},
  author={Lu Wang and Toru Motoi and Raya Khanin and Adam B. Olshen and Fredrik Mertens and Julia Bridge and Paola Dal Cin and Cristina R Antonescu and Samuel Singer and M. Muzaffar Hameed and Judith V M G Bov{\'e}e and Pancras Cornelis Wilhelmus Hogendoorn and Nicholas B Socci and Marc Ladanyi},
  journal={Genes, chromosomes & cancer},
  year={2012},
  volume={51 2},
  pages={127-39}
}
Cancer gene fusions that encode a chimeric protein are often characterized by an intragenic discontinuity in the RNA\expression levels of the exons that are 5' or 3' to the fusion point in one or both of the fusion partners due to differences in the levels of activation of their respective promoters. Based on this, we developed an unbiased, genome-wide bioinformatic screen for gene fusions using Affymetrix Exon array expression data. Using a training set of 46 samples with different known gene… CONTINUE READING