Identification of a novel, nanobody-induced, mechanism of TAFI inactivation and its in vivo application.


BACKGROUND Down-regulation of fibrinolysis due to cleavage of C-terminal lysine residues from partially degraded fibrin is mainly exerted by the carboxypeptidase activity of activated thrombin-activatable fibrinolysis inhibitor (TAFIa). Recently, some intrinsic carboxypeptidase activity (i.e. zymogen activity) was reported for the proenzyme (TAFI); however… (More)
DOI: 10.1111/jth.12473

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