Identification of a new region of SARS-CoV S protein critical for viral entry.

@article{Guo2009IdentificationOA,
  title={Identification of a new region of SARS-CoV S protein critical for viral entry.},
  author={Ying Chun Guo and Jennifer R. Tisoncik and Susanna McReynolds and Michael Farzan and Bellur S Prabhakar and Thomas G. Gallagher and Lijun L Rong and Michael G. Mc Caffrey},
  journal={Journal of molecular biology},
  year={2009},
  volume={394 4},
  pages={
          600-5
        }
}
Infection by severe acute respiratory syndrome coronavirus (SARS-CoV) is initiated by specific interactions between the SARS-CoV spike (S) protein and its receptor ACE2. In this report, we screened a peptide library representing the SARS-CoV S protein sequence using a human immunodeficiency virus-based pseudotyping system to identify specific regions that affect viral entry. One of the 169 peptides screened, peptide 9626 (S residues 217-234), inhibited SARS-CoV S-mediated entry of the… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

Similar Papers

Loading similar papers…