Identification of a new metalloproteinase inhibitor that forms tight-binding complexes with collagenase.

@article{Cawston1990IdentificationOA,
  title={Identification of a new metalloproteinase inhibitor that forms tight-binding complexes with collagenase.},
  author={Timothy E Cawston and Valerie A. Curry and Ian M Clark and Brian L. Hazleman},
  journal={The Biochemical journal},
  year={1990},
  volume={269 1},
  pages={183-7}
}
Connective-tissue cells produce a family of metalloproteinases which, once activated, can degrade all the components of the extracellular matrix. These potent enzymes are all inhibited by the tissue inhibitor of metalloproteinases (TIMP), and it was thought that the levels of this inhibitor controlled the extracellular activity of these enzymes. We recently detected a new metalloproteinase inhibitor present in culture media of WI-38 fibroblasts. The inhibitor, named 'large inhibitor of… CONTINUE READING

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