Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids.

@article{Schmidt1992IdentificationOA,
  title={Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids.},
  author={Azriel Schmidt and Naoto Endo and Su Jane Rutledge and Roland Vogel and D Shinar and Gideon A. Rodan},
  journal={Molecular endocrinology},
  year={1992},
  volume={6 10},
  pages={1634-41}
}
We have identified a novel member of the steroid hormone receptor superfamily by cDNA cloning from a human osteosarcoma SAOS-2/B10 cell library. Sequence analysis predicts a protein of 441 amino acids, which includes the conserved amino acid residues characteristic of the DNA- and ligand-binding domains of nuclear receptors. Amino acid sequence alignment and transcriptional activation experiments revealed that the new protein is closely related to the mouse peroxisome proliferator activated… CONTINUE READING
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