Identification of a new locus for a peculiar form of congenital muscular dystrophy with early rigidity of the spine, on chromosome 1p35-36.

@article{Moghadaszadeh1998IdentificationOA,
  title={Identification of a new locus for a peculiar form of congenital muscular dystrophy with early rigidity of the spine, on chromosome 1p35-36.},
  author={Behzad Moghadaszadeh and Isabelle Desguerre and Haluk Topaloğlu and Francesco Muntoni and Sylvana Pavek and Caroline S Sewry and Mich{\`e}le Mayer and Michel Fardeau and Fernando M. S. Tom{\'e} and Pascale Guicheney},
  journal={American journal of human genetics},
  year={1998},
  volume={62 6},
  pages={1439-45}
}
Classical congenital muscular dystrophies (CMDs) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness, atrophy of limbs and trunk muscles, contractures, and dystrophic changes in the muscle biopsy. So far, only one gene, LAMA2 (6q2), which encodes the laminin alpha2 chain (or merosin), has been identified in these disorders. Mutations in LAMA2 cause CMD with complete or partial merosin deficiency, detectable by immunocytochemistry on muscle… CONTINUE READING

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Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
Classical congenital muscular dystrophies ( CMDs ) are autosomal recessive neuromuscular disorders characterized by early onset of hypotonia and weakness , atrophy of limbs and trunk muscles , contractures , and dystrophic changes in the muscle biopsy .
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