Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor.

@article{Sajjadi1991IdentificationOA,
  title={Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor.},
  author={Fereydoun G. Sajjadi and Elena B Pasquale and Suresh Subramani},
  journal={The New biologist},
  year={1991},
  volume={3 8},
  pages={769-78}
}
We have identified cDNA clones that encode a new member of the Eph receptor tyrosine kinase subclass by using antibodies to phosphotyrosine to screen a chicken embryonic cDNA expression library. These cDNAs were in turn used to isolate the entire coding sequence of this receptor from both mouse and chicken (designated Mek4 and Cek4, respectively). A cDNA that encodes a putative secreted form of the murine receptor's ligand-binding domain and lacks the transmembrane and kinase domains was also… CONTINUE READING