Identification of a new class of small molecule C5a receptor antagonists.


C5a is a terminal product of the complement cascade that activates and attracts inflammatory cells including granulocytes, mast cells and macrophages via a specific GPCR, the C5a receptor (C5aR). Inhibition of C5a/C5aR interaction has been shown to be efficacious in several animal models of autoimmune diseases, including RA, SLE and asthma. This account… (More)
DOI: 10.1016/j.bmcl.2009.11.058


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