Identification of a new class of small molecule C5a receptor antagonists.

@article{Chen2010IdentificationOA,
  title={Identification of a new class of small molecule C5a receptor antagonists.},
  author={Jack J Chen and Derek C Cole and Greg Ciszewski and Kimberly Crouse and John W Ellingboe and Pawel M. Nowak and Gregory J. Tawa and Gabriel Berstein and Wei Li},
  journal={Bioorganic & medicinal chemistry letters},
  year={2010},
  volume={20 2},
  pages={662-4}
}
C5a is a terminal product of the complement cascade that activates and attracts inflammatory cells including granulocytes, mast cells and macrophages via a specific GPCR, the C5a receptor (C5aR). Inhibition of C5a/C5aR interaction has been shown to be efficacious in several animal models of autoimmune diseases, including RA, SLE and asthma. This account… CONTINUE READING