Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines.

@article{Protopopova2005IdentificationOA,
  title={Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines.},
  author={Marina S. Protopopova and Colleen F Hanrahan and Boris V. Nikonenko and Rowena Samala and Ping Chen and Jackie Gearhart and Leo 4 Einck and Carol Ann Nacy},
  journal={The Journal of antimicrobial chemotherapy},
  year={2005},
  volume={56 5},
  pages={
          968-74
        }
}
OBJECTIVES The aim of this study was to identify a candidate drug for clinical development from a previously synthesized combinatorial library based on the 1,2-ethylenediamine structure of ethambutol. METHODS Sixty-nine of the most potent hits against Mycobacterium tuberculosis from the original studies were subjected to a sequential set of tests in vitro and in vivo--determination of MIC for M. tuberculosis H37Rv, cytotoxicity, intracellular antimycobacterial activity, permeability… CONTINUE READING

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