Identification of a new C-terminal splice variant of CaV1.3 L-type calcium channels with unique functional properties

Abstract

Background In L-type voltage-gated calcium channels (VGCCs) the long C-terminal tail contains several sites for modulation by protein-protein interaction. CaV1.3 VGCCs (CaV1.3L) activate at negative voltages and support sinoatrial node pacemaking and hearing, and shape neuronal excitability. In CaV1.3L an intermolecular automodulatory C-terminal interaction… (More)

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