Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization.

@article{Hirano1992IdentificationOA,
  title={Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization.},
  author={Shigeru Hirano and Naoya Kimoto and Yutaka Shimoyama and Setsuo Hirohashi and Masatoshi Takeichi},
  journal={Cell},
  year={1992},
  volume={70 2},
  pages={293-301}
}
The function of cadherin cell adhesion molecules is thought to be regulated by a group of cytoplasmic proteins, including alpha-catenin. We identified a subtype of alpha-catenin, termed alpha N-catenin, which is associated with N-cadherin and expressed mainly in the nervous system. cDNA transfection experiments showed that alpha N-catenin can also bind with E-cadherin. To investigate the role of alpha N-catenin, we transfected lung carcinoma PC9 cells, which express E-cadherin and beta-catenin… CONTINUE READING
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