Identification of a mutation associated with erythromycin resistance in Bordetella pertussis: implications for surveillance of antimicrobial resistance.

@article{Bartkus2003IdentificationOA,
  title={Identification of a mutation associated with erythromycin resistance in Bordetella pertussis: implications for surveillance of antimicrobial resistance.},
  author={Joanne M. Bartkus and Billie Anne Juni and Kristen R Ehresmann and Cheryl A. Miller and Gary N. Sanden and Pamela K. Cassiday and Michael A. Saubolle and Bokkwon Lee and J Long and A. R. Harrison and John M. Besser},
  journal={Journal of clinical microbiology},
  year={2003},
  volume={41 3},
  pages={1167-72}
}
Erythromycin treatment failures and in vitro resistance of Bordetella pertussis have been reported on several occasions in the past few years, but the mechanism of resistance has not been described. One potential mechanism, genetic modification of the erythromycin-binding site on the 23S rRNA of the 50S ribosomal subunit, has been observed in other bacteria. To explore this possibility, we amplified the portion of the 23S rRNA gene encoding the central loop of domain V. DNA sequencing and… CONTINUE READING
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