Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice.

@article{Misawa2002IdentificationOA,
  title={Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice.},
  author={Hidemi Misawa and Elliott H. Sherr and David Jay Lee and Dane M. Chetkovich and Andrew Tan and Christoph E. Schreiner and David S Bredt},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 23},
  pages={
          10088-93
        }
}
  • Hidemi Misawa, Elliott H. Sherr, +4 authors David S Bredt
  • Published in
    The Journal of neuroscience…
    2002
  • Biology, Medicine
  • Epilepsy is a debilitating disease with a strong genetic component. Positional cloning has identified a few genes for rare monogenic epilepsy syndromes; however, the genetics of common human epilepsies are too complex to be analyzed easily by current techniques. Mouse models of epilepsy can further this analysis by eliminating genetic background heterogeneity and enabling the production of sufficient numbers of offspring. Here, we report that Black Swiss mice have a heretofore unrecognized… CONTINUE READING

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