Identification of a monoclonal antibody specific for a murine T3 polypeptide.

  title={Identification of a monoclonal antibody specific for a murine T3 polypeptide.},
  author={Oberdan Leo and M H Foo and David H Sachs and Lawrence E Samelson and Jeffrey A Bluestone},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={84 5},
A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-epsilon) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-epsilon as a cell surface protein involved in the transduction of activation signals. 
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.
357 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 357 extracted citations

Similar Papers

Loading similar papers…