Identification of a monoclonal antibody specific for a murine T3 polypeptide.

@article{Leo1987IdentificationOA,
  title={Identification of a monoclonal antibody specific for a murine T3 polypeptide.},
  author={Oberdan Leo and M H Foo and David H Sachs and Lawrence E Samelson and Jeffrey A Bluestone},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 5},
  pages={1374-8}
}
A monoclonal antibody (145-2C11) specific for the murine T3 complex was derived by immunizing Armenian hamsters with a murine cytolytic T-cell clone. The antibody is specific for a 25-kDa protein component (T3-epsilon) of the antigen-specific T-cell receptor. It reacts with all mature T cells and can both activate and inhibit T-cell function. These results identify T3-epsilon as a cell surface protein involved in the transduction of activation signals. 
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