Identification of a molecular recognition feature in the E1A oncoprotein that binds the SUMO conjugase UBC9 and likely interferes with polySUMOylation

@article{Yousef2010IdentificationOA,
  title={Identification of a molecular recognition feature in the E1A oncoprotein that binds the SUMO conjugase UBC9 and likely interferes with polySUMOylation},
  author={Ahmed F. Yousef and Gregory Fonseca and Peter Pelka and Jailal N. G. Ablack and Christine S Walsh and Frederick A Dick and D. P. Bazett-Jones and Gary S. Shaw and Joe S. Mymryk},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={4693-4704}
}
Hub proteins have central roles in regulating cellular processes. By targeting a single cellular hub, a viral oncogene may gain control over an entire module in the cellular interaction network that is potentially comprised of hundreds of proteins. The adenovirus E1A oncoprotein is a viral hub that interacts with many cellular hub proteins by short linear motifs/molecular recognition features (MoRFs). These interactions transform the architecture of the cellular protein interaction network and… CONTINUE READING

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